Listed below are the department's major divisions and programs linked to their respective web pages, where available.

Office of the Commissioner

• Division of Management and Administration
• Human Resources Services
• Office of Communications
• Office of Diversity and Equity Services
• Office of Legal and Regulatory Compliance

Office of Policy and Strategic Planning

• Health Information Technology 
• Center for Health Statistics
• Office of Vital Statistics and Registry
• Office of Minority and Multicultural Health
• Quality Improvement
• Commissions – Autism, Brain Injury, Spinal Cord Research
• Office of Health Care Quality and Assessment
• Strategic Initiatives

Public Health Services

• Office of the State Epidemiologist/Environmental and Occupational Health Services
  • Communicable Disease Service
  • Consumer, Environmental and Occupational Health Service
  • Cancer Epidemiology Services
• Division of HIV/AIDS, TB and STD Services
• Division of Family Health Services
• Division of Public Health Infrastructure, Laboratories and Emergency Preparedness
  • Public Health and Environmental Laboratories

Health Systems

• Division of Health Facilities Evaluation and Licensing
• Office of Health Care Financing