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Breast Cancer

Pink Ribbon What is it?
What puts me at risk?
Preventing Cancer
Screening for Early Detection
Treatment Options
Coping with Cancer
Statistics
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What is it?

  • An uncontrolled growth of abnormal breast cells.
  • Etiology of Breast Cancer
    • Cancer occurs when cells in a part of the body begin to grow out of control. Although there are many kinds of cancer, they all come about because of out-of-control growth of abnormal cells. Different kinds of cancer can behave very differently.
  • For more detailed information about Breast Cancer:

What puts me at risk?

  • The risk of breast cancer increases greatly with age.
  • Family history, familial cancer syndrome.
  • Reproductive and hormonal factors such as early menarche (early onset of menstruation), late menopause, late parity (bearing children late), and nulliparity (not bearing children).
  • Certain types of benign breast disease (fibrocystic, fibroadenoma)
  • Obesity after menopause.
  • Moderate to heavy alcohol consumption (3 or more drinks per day).
  • Very high doses of radiation, such as that used in radiation therapy.
  • Long-term use of estrogen replacement therapy after menopause.
  • Lack of physical activity and a diet high in fat.

For more detailed information on family history, log onto:
U.S. Surgeon General’s Family History Initiative


Preventing Cancer

  • Tamoxifen- In terms of primary prevention, tamoxifen, a selective estrogen-receptor modulator, has been shown to reduce breast cancer incidence among women at elevated breast cancer risk. Five-year adjuvant treatment of tamoxifen has also been shown to significantly reduce recurrence of secondary malignancies in early stage breast cancer patients.
  • Genetic testing- The "breast cancer gene," BRCA1, was identified in 1994 and BRCA2 in 1995. A positive on a mutation test result indicates enhanced breast and ovarian cancer risk - either higher risk of an initial cancer (for unaffected women) or a recurrence or second primary cancer (for women already affected by cancer). Women with BRCA1 or BRCA2 mutations have approximately a 33% to 50% risk of developing breast cancer by age 50.
  • Suppression of hormonal factors- Hormones produced by the ovaries appear to increase a woman's risk for developing breast cancer. The removal of one or both ovaries reduces the risk. The use of drugs that suppress the production of estrogen may inhibit tumor cell growth. The use of hormone replacement therapy may be associated with an increased risk of developing breast cancer, mostly in recent users. The use of oral contraceptives may also be associated with a slight increase in breast cancer risk. Beginning to menstruate at an older age and having a full-term pregnancy reduces breast cancer risk. Also, a woman who has her first child before the age of 20 experiences a greater decrease in breast cancer risk than a woman who has never had children or who has her first child after the age of 35. Beginning menopause at a later age increases a woman's risk of developing breast cancer.
  • Reducing radiation exposure- The key to preventing breast-cancer is to remove one of the necessary co-actors. Ionizing radiation is a major, proven, preventable cause of this disease. Every reduction in radiation dose is guaranteed to prevent a number of cases, which would otherwise occur.
  • Prophylactic mastectomy- Also called preventive mastectomy, it is the surgical removal of one or both breasts to try to prevent or reduce the risk of breast cancer. It involves removal of as much of the at-risk tissue as possible. Prophylactic mastectomy is seen as an option for several reasons.

    For more information- National Cancer Institute (http://cancernet.nci.nih.gov)
    or The Susan G. Komen Breast Cancer Foundation
    http://www.komen.org


Screening for Early Detection

  • Screening for cancer is examination (or testing) of people for early stages in the development of cancer even though they have no symptoms.

    Types of Screening

    • Breast Self-Examination (BSE) Some women perform monthly breast self-exams to check for any changes in their breasts. Women who notice anything unusual should contact their health care provider.
    • Clinical Breast Examination (CBE) - During a CBE, your doctor will carefully feel your breasts and under your arms to check for lumps or other unusual changes.
    • Mammogram - A mammogram is a special x-ray of the breast that can often find tumors that are too small for you or your doctor to feel.
    • Ultrasonography - Ultrasound is used to evaluate lumps that have been identified by BSE, CBE, or mammography, however, there is little evidence to support the use of ultrasound for screening the general population.
    • Magnetic Resonance Imaging (MRI) - A procedure in which a magnet linked to a computer is used to create detailed pictures of areas inside the body. MRI has been used to evaluate breast masses which can be felt and to discriminate between cancer and scar, but the role of MRI in breast cancer screening has not yet been established. Studies of screening MRI in women of high genetic risk are ongoing.

      For more information on screening services, log onto:
      Health Research & Educational Trust of New Jersey
      Early Detection Saves Lives: A Guide to Breast Cancer Screening Services in NJ

      New Jersey Cancer Education and Early Detection Services (NJCEED) – Breast Health Care

Treatment Options

  • Chemotherapy- Chemotherapy works by interfering with the cells ability to function and reproduce, usually by affecting DNA synthesis and/or function. It may be injected into the blood stream or taken as tablets.
  • Hormone Therapy- Hormonal therapy is used to prevent the growth, spread, or recurrence of breast cancer. If lab tests show that your tumor depended on your natural hormones to grow, it will be described as estrogen-positive or progesterone-positive in the lab report. This means that any remaining cancer cells may continue to grow when these hormones are present in your body. Hormonal therapy can block your body's natural hormones from reaching any remaining cancer cells (ex. Tamoxifen).
  • Radiation- Therapy that uses high energy rays or particles to treat disease. High doses of radiation can kill cells or keep them from growing and dividing.
  • Radiotherapy- The use of x-rays and other forms of radiation in an attempt to destroy malignant cells and tissue. There are various forms or methods, most now conducted with computers.
  • Biological Therapy- This treatment uses materials produced by the body or manufactured in a laboratory to boost, direct, or restore your body's natural defenses against disease. One type of biological therapy called biological response modifier (BRM) therapy, or immunotherapy, is sometimes used to treat cancer.

    All of these treatments can be described in detail at: http://www.nci.nih.gov/cancerinfo/treatment/breast

  • Create an account on the American Cancer Society webpage to help you understand your treatment options and probable side effects.
    http://www.cancer.nexcura.com/Interface2.asp?CB=266&NewSession
  • For information on surgery choices, log onto:
    National Cancer Institute – Surgery Choices for Women with Early Stage Breast Cancer [En Espanol]
  • For information on finding a doctor or treatment facility, log onto: http://www.cancer.gov/cancertopics/factsheet/Therapy/doctor-facility

Clinical Trials

Coping with Cancer


Statistics

Comprehensive Cancer Control Plan
National Center for Health Statistics – Fact Sheets
New Jersey State Cancer Registry

More Information


Department of Health and Senior Services

P. O. Box 360, Trenton, NJ 08625-0360
Phone: (609) 292-7837
Toll-free in NJ: 1-800-367-6543
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Last Modified: Thursday, 07-Feb-08 08:36:01